Antithymocyte globulin/methylprednisolone

Facilitation of metastasis by antithymocyte globulin.

Antithymocyte globulin (ATG) increases the number, size, and rate of appearance of pulmonary métastasesin mice from implants of the syngeneic Lewis lung carcinoma (3LL) without significantly increasing the weight of the primary tumor. An attempt was therefore made to deter mine whether this effect was due to an earlier release of malignant cells from the primary tumor or to facilitation of the...

Antithymocyte globulin and transplants for aplastic anemia.

have completed a study on the use of antithymocyte globulin (ATG) as part of the conditioning regimen for severe aplastic anemia (SAA) patients, undergoing an allogeneic stem cell transplant (HSCT) from matched sibling (MSD) or unrelated (UD) donors. The Authors have found that rabbit ATG (thymoglobulin, Sanofi, France), as compared to horse ATG (ATGAM, Pfizer, USA) is associated with less acut...

A Multicenter Trial of Antithymocyte Globulin in

One hundred fifty patients with bone marrow failure were treated in three groups with antithymocyte globulin (ATG; Upjohn. Kalamazoo, Ml) in a multicenter trial. Patients were assessed at 3, 6, and 1 2 months after initiation of treatment by three criteria: transfusion independence. clinical improvement, and blood counts. Group I consisted of 77 patients with acute severe aplastic anemia. rando...

Repeat course of rabbit antithymocyte globulin as salvage following initial therapy with rabbit antithymocyte globulin in acquired aplastic anemia.

Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.

BACKGROUND In severe acquired aplastic anemia, hematopoietic failure is the result of immune-mediated destruction of bone marrow stem and progenitor cells. Immunosuppressive therapy with antithymocyte globulin (ATG) plus cyclosporine is an effective alternative to stem-cell transplantation and improves blood counts and survival. Although horse ATG is the standard therapy, rabbit ATG is more pot...